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肝硬化患者电解质紊乱的临床分析 被引量:4

Electrolytes disorder in patients with cirrhosis
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摘要 目的探讨肝硬化患者电解质紊乱情况及其与肝功能Child-pugh分级的关系。方法对162例肝硬化患者肝功能Child-pugh分级、电解质情况及病情预后进行回顾性分析。结果肝硬化患者电解质紊乱以低Na^+最为常见,Na^+、K^+、C1^-3种离子均数与肝功能Child-pugh分级有关,尤其是Na^+和K^+。低Na^+、低K^+、低C1^-发生率随A、B、C分级程度的提高而呈上升趋势(P<0.01)。血Na^+水平越低,低K+、肝性脑病、顽固性腹水、死亡的发生率越高,而肝功能Child-pugh分级中的总胆红素、腹腔积液、白蛋白与血Na^+水平具有相关性.结论肝硬化患者电解质紊乱以低Na^+最为常见,血Na^+水平可作为判断肝硬化病情严重程度及预后的重要参考指标。 Objective To investigate the relationship between Child-Pugh degree of cirrhosis and electrolytes disorder. Methods The Child-Pugh degree, electrolytes and prognosis were analyzed retrospectively in 162 patients with cirrhosis. Results Low Na+ was mostly common in electrolytes disorder. The mean values of 3 electrolytes were associated with Child-Pugh degree, especially Na + and K+ The rate of electrolytes disorder was positively correlated with Child-Pugh degree. The Na+ levels were negatively correlated with the incidence rate of low K + ,hepatic encephalopathy, refractory ascites and death. Multiple regression analysis revealed that the level of Na + was correlated with total bilirubin, ascites and albumin. Conclusion Low Na+ is mostly common in electrolytes disorder of patients with liver cirrhosis and might be a reliable prognostic marker.
出处 《同济大学学报(医学版)》 CAS 2013年第2期58-61,共4页 Journal of Tongji University(Medical Science)
基金 国家自然科学基金(81070343) 上海市国际科技合作项目(09410705200)
关键词 肝硬化 CHILD-PUGH分级 电解质 低钠血症 预后 cirrhosis Child-Pugh degree electrolyte hyponatremia prognosis
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  • 1中华医学会传染病与,寄生虫病学分会,肝病学分会.病毒性肝炎防治方案[J].中华肝脏病杂志,2000,8(6):324-329. 被引量:14010
  • 2陈灏珠.实用内科学[M]12版.北京:人民卫生出版社,2005.1746-1750.
  • 3Salerno F, Guevara M, Bemardi M, et al. Refractory ascites: pathogenesis, definition and therapy of a severe complication in patients with cirrhosis [ J ]. Liver Int, 2010,30(7) : 937 -947.
  • 4Guevara M, Baccaro ME, Rios J, et al. Risk factors for hepatic encephalopathy in patients with cirrhosis and refractory ascites: relevance of serum sodium concentration [J]. Liver Int, 2010,30(8) : 1137 - 1142.
  • 5European Association for the Study of the Live. EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepato- renal syndrome in cirrhosis [ J]. J Hepatol, 2010,53 (3) : 397-417.
  • 6Gines P, Berl T, Bernardi M, et al. Hyponatremia in cirrhosis: from pathogenesis to treatment[ J]. Hepatology, 1998,28(3): 851-864.
  • 7Gines P, Cardenas A. The management of ascites and hyponatremia in cirrhosis [ J ]. Semin Liver Dis, 2008, 28(1):43-58.
  • 8Guevara M, Baccaro ME, Rios J, et al. Risk factors for hepatic encephalopathy in patients with cirrhosis and refractory ascites: relevance of serum sodium concentration [J].Liver Int, 2010, 30 ( 8 ) : 1137 - 1142.
  • 9Gines P, Guevara M. Hyponatremia in cirrhosis: pathogenesis, clinical significance, and management [ J]. Hepatology, 2008,48 ( 3 ) : 1002 - 1010.
  • 10Lv XH, Liu HB, Wang Y, et al. Validation of model for end-stage liver disease score to serum sodium ratio index as a prognostic predictor in patients with cirrhosis [J]. J Gastroenterol Hepatol, 2009, 24 ( 9 ) : 1547 - 1553.

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