膀胱癌尿蛋白表达的研究进展

Research progress on expression of urinary proteins in carcinoma of the bladder

膀胱癌是泌尿系统最常见的一种恶性肿瘤,分为肌层浸润性膀胱癌和非肌层浸润性膀胱癌,两者的治疗、预后有明显的不同。如何在早期区分两者对膀胱癌的治疗有很大的帮助。目前,膀胱癌的诊断以及复发的检测主要是靠膀胱镜和尿细胞学检查,以及CT、MRI等,但膀胱镜为有创性检查且费用昂贵,而尿细胞学检查敏感度很低,所以寻找一种无创可靠的标记物能快速准确地区分浸润性与非浸润性膀胱对临床治疗显得尤为重要。

The treatment and prognosis of muscle-invasive bladder cancer is different from non- muscle invasive bladder cancer. Urine cytology, cystoscopy, CT and MRI scans are commonly used for differential diagnosis of muscle-invasive and non-muscle invasive bladder cancers, but more sensitive, less expensive, non-invasive and more accurate method for diagnosis of bladder cancer need to be developed. This article reviews the expression of urinary proteins in the bladder cancer and their potential use as tumor markers in distinguishing invasive and non-invasive bladder cancers.