摘要
Wnt/β-catenin信号通路作为经典的Wnt信号转导通路参与调控细胞增殖、凋亡和分化等多种生物学过程。在胚胎着床和发育过程中,Wnt/β-catenin信号通路失活或其受体、配体的异常表达均可引起胚胎着床失败、器官分化异常、发育畸形甚至死亡。
Wnt/β-catenin signaling pathway is one of the classical Wnt signaling pathways involved in a variety of biological processes,such as cell proliferation,apoptosis and differentiation.Under physiological conditions,this pathway plays a role on embryonic implantation and development by improving cell proliferation and differentiation.On the other hand,the inactivation of Wnt/β-catenin signaling pathway or abnormal expressions of its receptors and ligands can cause implantation failure,organ maldifferentiation,embryonic malformation and even death.
出处
《生殖与避孕》
CAS
CSCD
2013年第5期328-332,共5页
Reproduction and Contraception
