原发性醛固酮增多症的分子机制研究进展

Research progress of molecular mechanism in primary hyperaldosteronism

原发性醛固酮增多症(PA)是内分泌疾病导致高血压的最常见形式,随着研究的深入,人们对PA发病机制的认识亦不断提高。PA分子机制的阐明对于全面认识并更好地治疗PA具有深远意义。文章从离子通道变异、信号通路改变及基因表达异常等方面,对PA发生和发展的研究进展作一综述,以期为更深入的研究启发新思路。

Primary hyperaldosteronism （PA） is the most common form of endocrine hypertension. With the deepening of studies, the understanding of the pathogenesis of PA has been greatly improved. Elucidating the molecular mechanism of PA has far-reaching significance for a better understanding and therapeutic strategy of PA. In this paper, the abnormalities of ion channel activity, signaling pathways, and gene expression in PA are reviewed, and new ideas are expected to achieve for further research.