预混还是基础：中国2型糖尿病患者起始胰岛素治疗的思考

Premixed or basal insulin ： the insulin initiation consideration in Chinese patients with type 2 diabetes mellitus

我国2型糖尿病患者血糖控制的总体情况并不乐观，胰岛素起始治疗较晚。且中国患者较早出现胰腺β细胞功能障碍和早期胰岛素分泌峰值降低。这些均可引起较严重的餐后高血糖，加上传统高碳水化合物饮食习惯的影响会使餐后高血糖更加严重。因此，预混胰岛素可能是中国2型糖尿病患者起始胰岛素治疗时比较合理的选择。

The general status of glycemic control and insulin initiation are not optimistic in Chinese patients with type 2 diabetes. Chinese patients experience pancreatic β-cell dysfunction and reduction of early phase insulin spike earlier and more severely compared to Caucasians. These can cause more significant postprandial hyperglycaemia which is further deteriorated by traditional carbohydrate-rich Chinese diet. Therefore, premixed insulin may be a more appropriate option of insulin initiation therapy for Chinese patients with type 2 diabetes mellitus.