摘要
用Con A—单克隆抗体夹心ELISA法,对107例肺癌、良性肺疾病患者和正常人血清中MG-Ags的表达进行了检测,以探讨肺癌患者血清中MG-AgS的表达情况及其在临床诊断中的意义。结果表明,36例肺癌的表达阳性率为64％,31例良性肺疾病的阳性率为19％,40例正常人的假阳性率为12.5％。癌与良性疾病和正常人之间阳性率差异非常显著(P<0.01),癌与良性肺疾病对照计算诊断效率为51.5％。故认为检测血清中MG—Ags的表达对肺癌的诊断有一定的临床意义。
The MG-Ags were detected in serum of ]07 patients with lung cancer and benign diseases of the lungs and normal persons using monoclonal antibodies MGs (MG7, MG5, MG9, MGd1) against gastric carcinoma. The positive rate was 64%(23/36) in lung cancers, 19%(6/31) in benign diseases of the lungs and 12.5%(5/40) in normal persons. The results suggested that MGs might be a new marker of lung cancers, and that detection of MG-Ags in serum of patient might provide some aid in the diagnosis of lung cancers.
关键词
血清学诊断
肺肿瘤
单克隆抗体
lung
neoplasm
antibodies, monoclonal
serodiagnosis
