仔兔白肌病病理学

Pathology of White Muscle Disease in Weanling Rabbits

目的观察仔兔白肌病病理改变。方法对发病仔兔进行病原微生物分离培养,大体剖检,选取骨骼肌、心肌、脊椎等脏器,用10%中性福尔马林固定,常规病理制片,HE及钙染色并进行病理组织学观察。结果全身骨骼肌广泛对称性肌营养不良,心肌及平滑肌也不同程度受累,其中有4只仔兔的皮下组织、骨骼肌及脊椎管内可见出血,2只合并球虫性肠炎。结论确诊仔兔所患疾病为白肌病,病理改变主要特征是全身骨骼肌广泛变性、凝固性坏死、间质结缔组织增生。

Objective To observe the pathological change in weanling rabbits with white muscle disease. Method Pathogenic microorganisms were isolated from weanling rabbits with white muscle disease and cultured. The rabbits were dissected, of which the skeletal muscle, cardiac muscle and spinal were isolated, fixed with 10% neutral formalin, prepared into routine tissue sections and observed for histopathology by HE and calcium staining. Result Generalized symmetric muscular dystrophy was observed in systemic skeletal muscle as well as partial cardiac muscle and smooth muscle. Bleeding was observed in subcutaneous tissue, skeletal muscle and spinal canal of four rabbits of which two were complicated with coccidial enteritis. Conclusion The disease in rabbit was diagnosed as white muscle disease, of which the main pathological characters included generalized denaturation and coagulative necrosis of systemic skeletal muscle and proliferation of interstitial connective tissue.