重症肺炎凝血功能变化的临床分析

A clinical analysis for changes of coagulation function in children with severe pneumonia

目的研究重症肺炎患儿血小板数目及凝血功能的改变和临床意义。方法比较92例重症肺炎患儿与70例非重症肺炎患儿血小板数目(PLT)以及凝血功能组合包括凝血酶原时间(PT)、部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、D-二聚体(DDI)检测结果并进行分析。结果重症组与非重症组比较,PLT差异无统计学意义(P>0.05),PT、APTT、TT和DDI升高,FIB降低,两组比较差异有统计学意义(P<0.01)。结论重症肺炎患儿易出现凝血功能障碍,检测肺炎患儿凝血功能可尽早判定病情严重程度。

Objective To investigate the changes of coagulation function and clinical significance in the children with severe pneumonia. Methods The number of platelet （PLT） and coagulation function were compared between 92 cases of children with severe pneumonia and 70 cases of children with non - severe pneumonia. The test results of the coagulation function including prothrombin time （PT） ,activated partial thromboplastin time （APTT）, thrombin time （TT）, fibrinogen （FIB） and D - dimers （DDI） were analyzed. Results When the group of severe pneumonia was compared with the group of non - severe pneumonia,there was no statistically difference between the two groups in the number of PLT（P 〉 0. 05）. The PT,APTT,TT and DDI were significantly increased and FIB was decreased in the group of severe pneumonia （P 〈 0. 01 ）. Conclusions The coagulation dysfunction are present in the children with severe pneumonia. The degree of severity of the pneumonia can be determined as early as possible by monitoring the coagulation function of the children with pneumonia, so the active treatment can be taken to the children with pneumonia.