瑞舒伐他汀对老年缺血型心肌病患者心功能的影响

Effects of rosuvastatin on cardiac function in older patients with ischemic cardiomyopathy

目的探讨瑞舒伐他汀对老年缺血型心肌病患者血清BNP水平与心功能的影响。方法 60老年缺血型心肌病患者被随机分为瑞舒伐他汀治疗组(30例)和对照组(30例),采用放射免疫方法检测各组治疗前后血清中BNP的水平,并作心脏超声检查及6min步行试验,评估心功能。结果瑞舒伐他汀组与对照组治疗后血清BNP水平均较治疗前明显下降(P<0.05),且瑞舒伐他汀组较对照组治疗后血清中降低更明显(P<0.05);治疗后瑞舒伐他汀治疗组左室射血分数、左室收缩末容积、左室舒张末容积指数及6min步行试验较对照组明显改善(P<0.05)。结论瑞舒伐他汀能降低老年缺血型心肌病患者血浆BNP水平,改善心脏功能,有益于缺血型心肌病的治疗。

Objective To investigate the effects of rosuvastatin on cardiac function and serum levels of BNP in older patients with ischemic cardiomyopathy. Methods The levels of serum BNP were determined by radioimmunoassay in 60 cases,Patients were randomly assigned to rosuvastatin group and control group. 30 patients were treated by rosuvastatin in rosuvastatin group and other 30 were treated by routine treatment in control group. Before and after treatment, the heart function was evaluated by echocardiogram and the walk of 6 minutes was done. Results The levels of BNP after treatment in both group significantly decreased （ P 〈 0. 05 ） , the BNP levels in rosuvastatin group decrease more significant compared with control group （P 〈 0.05）. The heart function index ： LVEF, LVEDD,LVEDV,the walk of 6 minutes in therapy group significantly improved compared with routine therapy group （ P 〈 0. 05 ）. Conclusions Short term rosuvastat improves cardiac function, reduces levels of BNP associated with ischemic cardiomyopathy. This field would benefit for ischemic cardiomyopathy.