环状磷酸催化合成二吲哚甲烷衍生物

Synthesis of Bis(indolyl)methanes Catalyzed by Cyclic Phosphoric Acid

在环状磷酸催化下,通过吲哚和醛酮的亲电取代反应,室温下合成了一系列二吲哚甲烷衍生物.考察了催化剂结构、用量和溶剂等因素对反应的影响,确定了最优反应条件,提出了可能的反应机理.该方法具有操作简单、条件温和、催化剂用量少、产率高及环境友好等优点.

Cyclic phosphoric acid was found to be an efficient Bronsted acid catalyst for the eleetrophilic substitution reaction of indole with aldehydes or ketones in dichloromethane to afford the corresponding bis（indolyl）rnethanes in excellent yields at room temperature. The influence of catalyst structure, catalyst loading and reaction media was investigated, the optimal reac- tion conditions were obtained and a possible mechanism for the reaction was proposed. The simple procedure, mild reaction conditions, low catalyst loading, high yield and environmentally friendly organocatalyst provide a valuable approach for the preparation of bis（indolyl）methanes.