α-苯偶姻肟的绿色合成及其顺、反异构体的选择性控制与分离

Green Synthesis of α-Benzoin Oxime, and the Selective Control and Separation of Its Cis-Trans Isomers

报道了一种α-苯偶姻肟的合成及其顺、反异构体的分离方法.以苯甲醛为原料,双正离子咪唑盐为催化剂,通过氮杂卡宾机理合成了中间体α-苯偶姻,该方法条件温和,成本较低,环境友好,收率较高.在α-苯偶姻肟化生成α-苯偶姻肟的反应中,通过调节反应温度,得到了互为顺、反异构体的两种初产物,并采用梯度淋洗的柱层析法将两种异构体完全分离.

A synthesis and isolation method for a-benzoin oxime was reported. With benzaldehyde as starting material and dicationic imidazolium salt as catalyst, a-benzoin as an important intermediate was synthesized through the mechanism of nitrogen heterocyclic carbine. This method is characterized by mild conditions, low cost, environment friendly and good yield. In the a-benzoin oximation reaction, adjusting the reaction temperature can get selective control of oxime structure for cis-trans isomers which were completely separated by column chromatography using gradient elution.