聚丙烯酸钠和丝素蛋白自膨胀水凝胶的制备及其释药性能

Preparation of the Self-inflating Hydrogels Based on Poly(sodium acrylate) and Silk Fibroin and Their Drug Releasing Properties

通过自由基聚合的方法合成制备了自膨胀PAAS-SF semi-IPN水凝胶(聚丙烯酸钠-丝素半互穿网络水凝胶),并进一步探讨其作为微创治疗中组织植入物的潜能.主要研究了SF(丝素蛋白)和AA(丙烯酸)的重量比对PAAS-SFsemi-IPN水凝胶的结构、膨胀性以及力学性能的影响.此外,我们还研究了抗生素药物阿莫西林(AMO)在PAAS-SFsemi-IPN水凝胶中的包载与释放性能.结果表明,随着水凝胶中SF含量的增加,膨胀率增大,压缩强度减小,药物释放速率加快,且PAAS-SF20 semi-IPN水凝胶在120 h内能释放(83.4±0.9)%的药物.所开发的自膨胀PAAS-SFsemi-IPN水凝胶具有高膨胀率和良好的药物释放能力,将在药物输送或其它植入材料领域有良好的应用前景.

A self-inflating hydrogel based on silk fibroin （SF） and poly（sodium acrylate） （PAAS） was synthesized by the free radical copolymerization. Furthermore, its potential as a tissue implant with minimally invasive treatment was investigated. The effects of the weight ratio of SF to AA （acrylic acid） on the structure, swelling properties and mechanical properties of the PAAS-SF semi-IPN hydrogels were investigated. In addition, the loading and release of amoxicillin of the PAAS-SF semi-IPN hydrogels were studied. With increasing SF content in the hydrogels, the swelling ratio and the rate of drug release increased, while the compressive strength decreased. It was observed that （83.4 ± 0.9）% of the loaded drug was released within 120 h for the PAAS-SF20 semi-IPN hydrogels. The results revealed that the self-inflating PAAS-SF semi-IPN hydrogels with high swelling ratio and good drug releasing capabilities may have potential in the drug delivery or other implantable materials.