期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

骨钙素与老年2型糖尿病的相关性研究 被引量：4

Correlation between serum osteocalcin and type 2 diabetes mellitus in elderly patients
原文传递
导出
摘要 目的 研究老年2型糖尿病患者血糖、胰岛素、胰岛素抵抗指数、骨密度与骨钙素的相关性. 方法 选择55例2型糖尿病患者和50例非糖尿病对照者,年龄均≥60岁,比较两组间的空腹血糖（FBG）、糖化血红蛋白（HbAlc）、空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA-IR）、骨钙素、体质指数（BMI）,骨密度,分析血清骨钙素水平与各项指标的相关性. 结果 对照组的骨钙素[（11.2±3.2） μg/L比（4.1±3.0）μg/L]、骨密度（-1.3±0.3比-2.6±0.5）高于老年2型糖尿病组,空腹血糖[（4.7±2.0） mmol/L比（9.4±2.1） mmol/L]、糖化血红蛋白[（4.8±1.5）％比（7.6±1.6）％]、胰岛素[（7.4±3.2） U/L比（23.7±3.0） U/L]、胰岛素抵抗指数（1.5±0.7比9.9±1.2）低于老年2型糖尿病组（P＜0.05）.骨钙素与老年2型糖尿病患者的FBG、HbAlc、FINS、HOMA-IR呈负相关（r=-0.739、-0.713、-0.613、-0.092,均P＜0.05）,骨钙素与骨密度呈正相关（r=0.269,P＜0.05）. 结论 血清骨钙素水平与老年2型糖尿病患者的血糖水平及胰岛素抵抗程度相关. Objective To investigate the correlation between serum osteocalcin and type 2 diabetes mellitus （T2DM） in elderly patients.Methods A total of 55 T2DM patients （diabetic group） and 50 non-diabetic subjects （control group） aged ≥60 years were enrolled in this study.The levels of fasting blood glucose （FBG）,glycated hemoglobin （HbAlc）,insulin resistance index （HOMA IR）,osteocalcin （OC）,body mass index （BMI） and bone mineral density （BMD） in groups were compared.The correlations between serum osteocalcin and the above indicators were analyzed.Results The levels of OC and BMD were higher in control group than in diabetic group [（11.2±3.2）μg/Lvs.（4.1±3.0）μg/L,（-1.3±0.3） vs.（-2.6±0.5）,respectively,both P〈0.05].The levels of FBG,HbAlc,FINS,HOMA-IR were lower in control group than in diabetic group [（4.7±2.0） mmol/L vs.（9.4±2.1） mmol/L],[（4.8±1.5） % vs.（7.6±1.6）%,（7.4±3.2） U/L vs.（23.7±3.0） U/L,（1.5±0.7） vs.（9.9±1.2）,respectively,all P〈0.05].Serum osteocalcin concentration was negatively correlated with the levels of FBG,HbAlc,FINS and HOMA-IR in elderly patients with T2DM （r=-0.739,-0.713,-0.613,-0.092,all P〈0.01）.Conclusions Serum osteocalcin concentration is correlated with the levels of blood sugar and insulin resistance index in elderly patients with T2DM.A further study on the correlation between osteocalcin and T2DM may provide a new target for the treatment of type 2 diabetes mellitus.
作者 邓捷 朱亦堃 史书红 李兴 赵宝珍
机构地区 山西长治市城区第二医院内分泌科 山西医科大学第二医院内分泌科
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2013年第5期510-512,共3页 Chinese Journal of Geriatrics
关键词 糖尿病2型 骨钙素 Diabetes mellitus, type 2 Osteocalcin
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献8

  • 1Aonuma H, Miyakoshi N, Hongo M, et al. Low serum levels of undercarboxylated osteocalcin in post menopausal osteoporotic women receiving an inhibitorof bone resorption. Tohoku J Exp Med, 2009,218: 201-205.
  • 2Gamero P. Biomarkers for osteoporosis management.. untility in diagnosis, fracture risk prediction and therpy monitoring. Mol Diagn Ther, 2008, 12: 157- 159.
  • 3Lee N,Sowa H, Hinoi E, et al. Endocrine regulation of energy metabolism by the skeleton. Cell, 2007, 130:456 469.
  • 4DennisonE, Syddall H, Aihie A, et al. Type 2 diabetes mellitus is associated with increased axial bone density in men and women from the Hertfordshire cohort study., evidence for an indirect effect of insulin resistance? Diabetologia, 2004, 47:1963-1968.
  • 5Gerdhem P, Isaksson A, Akesson K, et al. Increased bone density and decreased bone turnover, but no evident alteration of fracture susceptibility jn elderly women with diabets mellitus. Osteoporos Int, 2005, 16:1506-1512.
  • 6Witttrant Y,Gorin Y,Woodreff K,et al. High D(+) glucose concentration inhibits RANKL induced osteoclastogenesis. Bone, 2008,42 : 1122-1130.
  • 7Hwang Y,Jeong I , Ahn K , et al. The uncarboxylated from osteocalcin is associated with improved glucose tolerance and enhanced l-cell function in middle-aged male subjects. Diabetes Metab Res Rev, 2009,25 : 768- 772.
  • 8Schwartz AV. Diabetes mellitus: does it affect bone. Caleif Tissure Int,2003,73 : 515-519.

同被引文献42

  • 1全国eGFR课题协作组.MDRD方程在我国慢性肾脏病患者中的改良和评估[J].中华肾脏病杂志,2006,22(10):589-595. 被引量：702
  • 2中华医学会糖尿病学分会.中国2型糖尿病防治指南(2010版)[J].中国糖尿病杂志,2012,20: s1-s37.
  • 3Lee NK,Sowa H, Hinoi E,et al. Endocrine reguletion of energy metabolism by the skeleton [J]. Cell, 2007, 130 (3) :456-469.
  • 4Kanazawa I, Yamaguchi T, Yamamoto M, et al. Serum os-teocalcin level is associated with glucose metabolism and atherosclerosis parmeters in type 2 diabetes mellitus[J]. J Clin Endocrinol Metab,2009,94(1):45-49.
  • 5Witttrant Y,Gorin Y,Woodreff K,et al. High d(+)glu- cose concentration inhibits RANKL-induced osteoclasto- genesis[J]. Bone,2008,42(6) :1122-1130.
  • 6Gerdhem P, Isaksson A, Akesson K, et al. Increased bone density and decreased bone turnover, but no evident alter- ation of fracture susceptibility jn elderly women with dia- bets mellitus [ J ]. Osteoporos Int, 2005, 16 ( 12 ) : 1506- 1512.
  • 7Lee NK, Sowa H, Hinoi E, et al, Endocrine regulation of energy metabolism by the skeleton [J]. Cell, 2007, 130 (3) :409-411.
  • 8Ferron M, McKee MD, Levine RL, et al. Intermittent in- jections of osteoealein improve glucose metabolism and prevent type 2 diabetes in mice[J]. Bone, 2012,50 (2): 568-575.
  • 9Lee NK, Sowa H, Hinoi E, et al. Endocri- ne regulation of energy metabolism by the skeleton[J].Cell, 2007, 130(3): 456-469.
  • 10Ferron M, Hinoi E, Karsenty G, et al.Oste- ocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice[J]. Proc Natl Acad Sci USA,2008,105( 13): 5266-5270.

引证文献4

二级引证文献22

中华老年医学杂志
2013年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部