细菌素及其应用的研究进展

Research Advance on Bacteriocin and its Application

细菌素是细菌自身生产的一类杀菌物质,由基因编码、核糖体合成,是自然界中细菌用于调节自身菌群结构的一类重要活性物质。细菌素的来源广泛、结构多样,对各种动物致病菌都具有高效抑杀作用,这些特点为细菌素开发成为一种新型抗菌药物提供了可能。作者对近年来在细菌素生物学特征的发展、分类更新及其应用研究等进行了综述,希望能为中国新型细菌素类动物药物的开发提供参考。

Bacteriocins,coded genetically and synthesized ribosomally,are a category of bactericidal peptides produced by bacteria.They play a key role in regulating environmental bacterial flora formation.With their wide resource,diverse structures and high potency in killing various pathogenic bacteria of animal diseases,bacteriocins are potentially developed into novel antimicrobials.This review focused on the research development of bacteriocin biological characteristics,the update of bacteriocin classification and the progress on application study of bacteriocins in last several years in order to throw some light on the development of novel bacteriocin veterinary drugs in China.