IL-17细胞因子家族调节黏膜免疫的研究进展

Research Progress on Regulation Mucosal Immune of IL-17 Cytokine Family

皮肤和黏膜上皮细胞既是机体的物理屏障,又是机体防御微生物的第一道防线。上皮细胞与白细胞、树突细胞(DCs)等之间的相互作用,是机体产生适应性免疫反应的重要因素。IL-17细胞因子家族是最近新发现的具有强大的促炎症作用的细胞因子,它们在机体的固有和适应性免疫中发挥着重要作用,IL-17A、IL-17C和IL-17F能够直接作用于组织的上皮细胞,诱导各种免疫反应来对抗病原体,且能够促进组织的修复。IL-17E最基本的作用是作用于白细胞和诱导Ⅱ型免疫,这在其对抗寄生虫的作用中是非常关键的,此外,IL-17E还可以反向调节白细胞对IL-17A和IL-17F的产生;而对于IL-17B和IL-17D的研究则相对较少一些。

Cutaneous and mucosal epithelial cells are a physical barrier and the first defense line of host against environmental changes.The crosstalk between epithelial cells,dendritic cells（DCs） and leukocytes play an important role in inducing proper immune responses during host defense.Interleukin-17（IL-17） family cytokines are cytokines discovered recently,playing important roles as powerful pro-inflammatory cytokines.They are important players in innate and adaptive immune response of host.IL-17A,IL-17C and IL-17F can directly target tissue epithelial cells to induce various antimicrobial responses against extracellular pathogens and promote tissue remodeling.By contrast,IL-17E primarily acts on leukocytes and induces type Ⅱ immunity that is crucial for protection against parasites.IL-17E also negatively regulates IL-17A and IL-17F production from leukocytes while reports are less on IL-17B and IL-17D.