DNA修复基因多态性与肺癌易感性的研究进展

Analysis of the relationship between DNA repair gene polymorphisms and lung cancer susceptibility

肺癌的发生与个体遗传易感性有关,其中DNA修复基因多态性可以引起不同DNA损伤反应,而机体间DNA损伤修复能力的不同与肺癌的发生有密切联系。DNA修复基因多态性与肺癌易感性的关系已成为当前的研究热点。本文回顾了DNA修复基因的作用机制及其多态性与肺癌易感性的国内外研究现状,就DNA损伤和修复类型、DNA不同修复途径相关基因的作用机制及其多态性与肺癌易感性的关系、DNA修复基因多态性与肺癌化疗敏感性的关系几个方面进行综述。

Lung cancer is associated with individual susceptibility. DNA repair gene polymorphisms lead to different DNA dam-age responses, and the occurrence of lung cancer is closely related to the diverse DNA repair capacities among individuals. The associa-tion of DNA repair gene polymorphisms with lung cancer susceptibility has become a focal point in lung cancer research. We examined local and international publications and reviewed the reported mechanisms of DNA repair genes as well as the relationship between polymorphisms of these genes and lung cancer susceptibility. Our review mainly includes the following：types of DNA damage and re-pair;different mechanisms of DNA repair genes and the relationship between their polymorphisms and lung cancer susceptibility;and association of DNA repair gene polymorphisms with sensitivity to chemotherapy during lung cancer.