摘要
缺血后适应对缺血再灌注损伤的心肌具有降低梗死面积,减少细胞凋亡及改善内皮功能等保护作用。后适应在临床应用中的可操作性,使其成为近年来心血管研究领域中的重点和热点。本文就缺血后适应在临床中的应用及研究进展做一综述。
Ischemic postconditioning had been observed to reduce infarct size and cell apoptosis on myocardial ischemia-reperfusion injury, and was also associated with a reduction in endothelial cell dysfunction and so on. Postconditioning is a fairly simple strategy, and seems possible to be applied in patients. We will review the advancements of protective effects and the mechanisms in myocardial ischemic postconditioning. The operability of postconditioning in clinical ap- plication makes it the focus and hotspots in the field of cardiovascular research in recent years. We will review the clinical application and study progress of myocardial ischemic postconditioning.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2013年第5期477-480,共4页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金(81170179)
教育部留学回国人员科研启动基金
关键词
心肌梗死
缺血后适应
缺血再灌注
再灌注损伤
Myocardial Infarction
Ischemic Postconditioning
Ischemia-Reperfusion
Reperfusion Injury
