PPR蛋白参与RNA编辑机制的研究进展

Research Progress on Relationship of PPR Proteins with RNA Editing

RNA编辑是一种发生在转录后核苷酸特异位点的加工修饰现象,包括核苷酸的插入、删除和改变。高等植物中RNA编辑主要发生在线粒体与叶绿体中,具有重要的生物学功能,其机制仍在探索中。而PPR蛋白作为RNA编辑的反式作用因子,成为近几年来分子生物学的研究热点。该文就PPR蛋白、RNA编辑及PPR蛋白参与RNA编辑的机制等进行了综述。

RNA editing is a post-transcription phenomenon of gene processing and modification at specific nucleotide sites,which including nucleotide insertion/deletion or nucleotide conversion.RNA editing mainly occurs at genomic of mitochondria and chloroplast in higher plants.It has many important biology functions,but the mechanism of this phenomenon is still unclear.During recently years,the PPR proteins,might be as trans-acting factor of RNA editing,has been put forward and become a research focus in molecular biology.In this review,we introduced PPR proteins,RNA editing and possibility interaction pattern between PPR proteins and RNA editing.