摘要
IL-33,IL-1家族新成员,在前炎性因子刺激下表达在多种细胞而且被认为在细胞裂解时释放出来。IL-33的受体ST2和IL-1RAP也广泛表达在多种细胞特别是Th2和肥大细胞表面。IL-33能保护宿主抗蠕虫感染;能促进Th2反应而降低动脉粥样硬化的发生。相反,IL-33同样能加重由肥大细胞介导的哮喘、关节炎、遗传性过敏皮炎及过敏反应等。IL-33可能作为这些疾病的新的治疗靶点。
Interleukin-33 （IL-33）, a newly described member of the IL-1 family, is expressed by many types of cell following pro-inflammatory stimulation and is thought to be released when cell lysis. The IL-33 receptor, consisting of ST2 and IL-1 receptor accessory protein, is also widely expressed, particularly by T helper 2 （Th2） cells and mast cells. IL-33 is host-protective against helminth infection and reduces atherosclerosis by promoting Th2-type immune responses. However, IL-33 can also promote the pathogenesis of asthma by expanding Th2 cells and mediate joint inflammation, atopic dermatitis and anaphylaxis by mast cell activation. Thus, IL-33 could be a new target for therapeutic intervention across a range of diseases.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2013年第6期535-539,共5页
Immunological Journal
基金
湖北省自然科学基金项目(2012FFB03708)
宜昌市科技攻关项目(A13301-02)
