葡萄糖代谢对卵母细胞成熟和植入前胚胎发育的影响

Effect of glucose metabolism on oocyte maturation and preimplantation embryo developmental competence

葡萄糖主要通过糖酵解途径、磷酸戊糖途径、己糖胺生物合成途径和多元醇途径进行代谢,在卵母细胞发育成熟及植入前胚胎发育过程中起重要作用。葡萄糖代谢异常,可导致卵母细胞成熟障碍和胚胎发育异常。本文对上述四条葡萄糖代谢途径在卵母细胞和植入前胚胎发育过程中的作用进行综述。进一步研究卵母细胞成熟和植入前胚胎发育过程中葡萄糖代谢途径的调控机制,有利于改善卵母细胞体外成熟和胚胎的培养条件,提高体外培养的卵母细胞和胚胎的发育能力。

Glucose can be metabolized by multiple pathways including glycolytic,pentose phosphate pathway,hexosamine biosynthetic and polyol pathway. Glucose metabolism plays an important role in oocyte maturation and preimplantation embryo development. The abnormality of glucose metabolism could result in disorder of oocyte maturation and embryo development. In this review, the role of glucose metabolism during oocyte maturation and embryo development was discussed. Further study of glucose metabolism regulation mechanism would benefit to improve culture condition for oocyte maturation and human preimplantation embryo development in vitro.