神经精神狼疮的MRI诊断

MRI Diagnosis of Neuropsychiatric Systemic Lupus Erythematosus

目的:探讨神经精神狼疮(NPSLE)的MRI表现特点。方法:回顾性分析2007年3月～2011年6月本院98例SLE患者头颅磁共振成像表现。结果:有36例诊断为神经精神狼疮,其头颅MRI改变主要有脑梗死14例,多发腔隙性缺血灶6例,梗死伴出血5例,脑萎缩5例,单纯脑出血4例等。患者颅内病灶数量多1～2个,可累及各脑叶、侧脑室旁、基底节区、脑干等,而发生在额叶和顶叶的病灶数量明显多于其他部位。结论:神经精神狼疮的脑MRI影像表现多样。对于无临床症状但高度怀疑为神经精神狼疮的SLE患者,进行头颅MRI检查在辅助诊断中可起到重要作用。

Purpose： To study the MRI manifestations of neuropsychiatric systemic lupus erythematosus （NPSLE）. Methods： The brain MRI manifestations of 98 SLE patients were retrospectively analyzed. Results： Of 98 SLE patients, 36 were diagnosed as NPSLE. The cerebral manifestations of NPSLE were infarction （14 cases）, multiple lacunar ischemic focus （6 cases）, infarction with hemorrhage （5cases）, atrophy （Scases）, hemorrhage （4 cases）, and so on. There were one or two lesions in most NPSLE. The location of the lesions involved all lobes of brain, para lateral ventricle, basal ganglia, brain stem and cerebellum, and most lesions were located in the frontal and parietal lobes. Conclusion： The MRI manifestations of NPSLE are varied, and brain MRI plays an important role in the diagnosis of the highly suspected NPSLE without clinic symptoms.