磁共振灌注加权成像评价交叉性小脑神经机能联系不能

MR perfusion in the evaluation of crossed cerebellar diaschisis

目的:利用磁共振灌注加权成像(PWI)探测急性脑梗塞后交叉性小脑神经机能联系不能(CCD)的发生机制及影响因素。方法:收集我院41例急性脑梗塞患者的PWI及扩散加权成像(DWI)信息,以健侧脑组织为对照,分析幕上脑梗塞的DWI病变体积及对侧小脑的脑血流量(CBF)、脑血容量(CBV)、达峰时间(TTP)及平均通过时间(MTT)的变化。结果:CCD阳性的患者较CCD阴性的患者幕上脑梗塞DWI病变体积显著升高(P<0.05);CCD阳性患者,对侧小脑的CBF较镜像侧显著性降低(P<0.05),TTP较镜像侧显著性延长(P<0.05),而CBV及MTT与镜像侧相比无显著性差异(P>0.05)。结论:PWI可用于研究幕上脑梗塞后对侧小脑CCD的发生机制及影响因素。

Objective： To determine the mechanism and influencing factors of crossed cerebellar diaschisis（CCD） observed in acute stroke with MR perfusion weighted imaging（PWI）.Methods： Collections of PWI and diffusion weighted image（DWI） information of 41 patients,infarct volume on DWI and cerebral blood flow（CBF）,cerebral blood volume（CBV）,time to peak（TTP） and mean transit time（MTT） of the contralateral cerebellum were comparatively analyzed with those of the opposite healthy hemicerebrum and hemicerebellum.Results： Infarct volume on DWI in the CCD patients are significantly larger than that of the non-CCD patients（P0.05）.Of the CCD patients,CBF of the contralateral cerebellum is substantially reducted compared to that of the opposite hemicerebellum（P0.05）,TTP of the contralateral cerebellum is substantially prolonged than that of the opposite hemicerebellum（P0.05）,but there is not statistically significant changes in CBF and MTT between the two hemicerebellum（P0.05）.Conlusion： PWI is useful for studying the occurring and the influencing factor of CCD after supratentorial infarct.