CGI-58在动物脂类代谢中的作用

Function of comparative gene identification-58 (CGI-58) on lipid metabolism in animals

细胞中脂滴(Lipid droplets,LDs)表面存在多个调控脂肪储存和分解的蛋白,这些蛋白对机体的脂肪代谢起着很重要的调控作用。CGI-58(Comparative gene identification-58)分布在LDs表面,属于α/β水解酶折叠家族,是脂肪甘油三酯脂肪酶(Adipose triglyceride lipase,ATGL)和依赖酰基辅酶A溶血磷脂酸酰基转移酶(Lyso-phosphatidic acid acyltransferase,LPAAT)的激活剂。在脂肪分解过程中,CGI-58结合PAT蛋白家族成员之一的脂滴包被蛋白(Perlipin)和ATGL,促进脂肪分解,同时CGI-58对ATGL的激活功能受脂滴包被蛋白家族成员间蛋白质与蛋白质相互作用的影响。文章结合国内外研究热点,针对CGI-58在动物脂类代谢中的作用进行了综述。

There are some proteins on the surfaces of lipid droplets （LDs） in the cells which could regulate the lipogenesis and lipolysis, and play an important role in lipid metabolism of the whole body. Comparative gene identification-58 （CGI-58）, distributing predominantly on the surface of LDs, which is a member of the α/β-hydrolase folding family and an activator of adipose triglyceride lipase （ATGL） and acyl-CoA-dependent lysophosphatidic acid acyltransfer （LPAAT）. CGI-58 promotes lipolysis by combining with perilipin which is a member of the PAT family and ATGL. At the same time, the function of CGI-58 to activate ATGL is influenced by protein-protein interaction with the members of the perilipin family. This paper reviews the CGI-58 function in lipid metabolism of animals considering the hot topics.