湿润烧伤膏对功能性鼻内镜术后黏膜恢复的疗效观察

Curative Effect of MEBO in Managing Mucosa Reparation after Functional Endoscopic Sinus Surgery

目的观察功能性鼻内镜术后局部应用湿润烧伤膏(MEBO)在黏膜修复过程中的影响。方法将191例功能性鼻内镜术后患者随机分为治疗组96例和对照组95例,治疗组于术后2 d～3 d取出鼻腔填塞物后给予湿润烧伤膏纱条贴敷创面治疗,2 d～3 d取出,用生理盐水冲洗术腔,鼻内镜下常规换药后用棉签将MEBO涂布于创面上;对照组于术后2 d～3 d取出鼻腔填塞物后仅采用常规鼻内镜术后换药及鼻腔冲洗治疗。结果治疗组较对照组术腔黏膜水肿消退快,结痂少,上皮化快,恢复良好。治疗组总有效率为92.7%,优于对照组的82.1%,差异有统计学意义(P<0.05)。结论湿润烧伤膏能减轻鼻内镜术后鼻腔黏膜水肿,促进黏膜修复,加速术腔黏膜上皮化,防止鼻腔黏膜黏连,可提高鼻内镜手术疗效,具有临床推广应用价值。

Objective To observe the curative effect of MEBO in topically managing mucosa reparation after functional endoscopic sinus surgery. Methods One-hundred and ninety-one patients after the functional endoscopic sinus surgeries were randomly divided into a treatment group of 96 patients and a control group of 95 patients. For the treatment group, 2 -3 days after the surgery, use MEBO gauze to cover wounds after taking out the nasal packing. Then 2 - 3 days later, use normal saline to wash nasal cavity and perform the routine dressing change under the endoscope and then smear MEBO evenly on the wound surface with cotton swab, while for the control group, 2 - 3 days post operation, only routine dressing change and nasal washing were performed after taking out the nasal packing. Results Compared with the control group, the treatment group realized better curative effects such as faster disappearance of mucosa edema, less scarring, faster epithelization and better reparation. The total effective rate in the treatment group was 92. 7% being superior to that of 82. 1% in the control group, with a difference of statistic significance （ P 〈 0. 05 ）. Conclusion MEBO can reduce post- operation mucosa edema, promote mucosa reparation, speed up mueosa epithelization and prevent the adhesion of nasal mucosa as well as enhance the curative effect of endoscopic sinus surgery, deserving to be promoted and applied in clinic.