乳腺导管原位癌超声图像特征及其与病理因素的关系

Ultrasound image features of ductal carcinoma in situ and their relations with pathological profiles

目的:观察乳腺导管原位癌(DCIS)超声图像特征,探讨其与Her-2蛋白表达等病理因素的关系。方法:回顾性分析66例乳腺导管原位癌的临床资料,分析患者超声图像的特征及肿块大小与钙化、浸润、Her-2表达的关系。结果:66例患者中,肿瘤>1 cm者42例,超声表现为形态不规则,边界不清的低回声区;肿瘤≤1 cm者24例,其中超声表现为导管扩张者7例,小结节9例,腺体增厚8例。超声检查肿块>1 cm的DCIS中,其钙化率低于≤1 cm者,但浸润率和Her-2阳性表达率均明显高于肿块≤1 cm者(均P<0.05)。超声检查诊断DCIS与病理结果的符合率为51%。结论:DCIS的超声表现具有特征性,肿块≤1 cm者常伴钙化,肿块>1 cm者提示预后不良。

Objective： To analyze the ultrasound image features of ductal carcinoma in situ（DCIS）,and their relations with the pathological pro les.Methods： e clinical data of 66 DCIS patients were reviewed,and then the ultrasound image features of the patients and the relationships between the lesion size and calci cation,in ltration and Her-2 expression were analyzed.Results： Of the 66 patients,the lumps in 42 cases were larger than 1 cm,which presented as hypoechoicareas with irregular shape and unclear border in the ultrasound image;the lumps in 24 cases were less than or equal to 1 cm,which presented as duct dilation（7 cases）,small nodule（9 cases）,or gland thickening（8 cases）.In DCIS larger than 1 cm,the calciication rate on ultrnsound examination was lower but iniltration and Her-2 positive expression rate were higher than those in DCIS less than or equal to 1 cm（all P0.05）.he coincidence rate of ultrasound examination for diagnosis of DCIS with the inal pathological results was 51%.Conclusion： DCIS has its own characteristics in ultrasound images,and the lump less than or equal to 1 cm is oten accompanied with calciication,while the lump larger than 1 cm may predict a poor prognosis.