单纯降压和降尿酸治疗高尿酸血症合并原发性高血压疗效分析

Curative effect of antihypertensive therapy and urate lowering therapy for patients with hyperuricemia and hypertension

目的探讨单纯合理降压治疗和降尿酸治疗高尿酸血症合并原发性高血压患者的临床疗效。方法将284例高尿酸血症合并原发性高血压患者随机分为降压组、降尿酸组。降压组给予合理抗高血压药物治疗,降尿酸组严格控制尿酸。所有患者分别在治疗前后检测血尿酸水平和血压水平,并进行统计学分析。结果降压组尿酸值明显低于治疗前,差异有统计学意义(P<0.01),降尿酸组收缩压和舒张压值低于治疗前,但无统计学意义。结论单纯合理有效控制血压可以改善血尿酸水平,单纯降尿酸治疗不能明显改善血压水平,对高尿酸血症合并原发性高血压患者需严格控制血压和血尿酸。

Objective To study the curative effect of antihypertensive therapy and urate lowering therapy for the patient both with hyperuricemia and hypertension. Methods All 284 cases of the patients with hyperuricemia and hypertension were divided into lowering blood pressure group and lowering uric acid group. The patients received only antihypertensive therapy in lowering blood pressure group, and observed the level of systolic blood pressure in lowering uric acid group. Diastolic blood pressure and the level of uric acid before and were evaluated before and after treatment. Results The level of uric acid in lowering blood pressure group were lower than that before treatment （P 〈 0.01 ）. The level of systolic blood pressure and diastolic blood pressure were lower than that before treatment in uric acid group, but there was no statistical significance. Conclusion Reasonable controlling of blood pressure could improve the level of uric acid, but only urate lowering therapy could not improve blood pressure. The blood pressure and uric acid of patients with both hyperuricemia and hypertension should be strictly controlled.