MMP-9/TIMP-1与COPD肺气肿关系研究进展被引量：13

Research Progress on Relationship of MMP-9/TIMP-1 and Emphysema Caused by COPD

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摘要慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是一种以进行性气流阻塞为特征的慢性呼吸道炎症性疾病,目前发病机制尚未明确。多数研究表明蛋白酶/抗蛋白酶机制是COPD的主要发病机制之一。其中基质金属蛋白酶9(MMP-9)/基质金属蛋白酶组织抑制剂1(TIMP-1)失衡对其发病尤为重要,且两者均参与肺气肿的形成。该文就近年MMP-9/TIMP-1与COPD肺气肿相关性的研究进展作一综述。 Chronic obstructive pulmonary disease （ COPD ）is a chronic inflammatory disease which is characterized by progressive airflow obstruction. The pathogenesis of chronic obstructive pulmonary disease is not completely clear yet. Most researches show that the mechanism of proteins/anti-protease is the main mechanism of COPD. Among these mechanisms, the imbalance of MMP-9/TIMP-1 makes an important contribution to the attack of the disease. And they both play equal role in the formation of emphysema. This article is designed to review the recent studies on the relationship between MMP-9/TIMP-1 and chronic obstructive emphysema.

作者蒋辉朱清艺毕迎春常燕王师超武松

机构地区安徽中医学院

出处《辽宁中医药大学学报》 CAS 2013年第6期108-110,共3页 Journal of Liaoning University of Traditional Chinese Medicine

基金安徽省自然科学基金项目(10040606Q38) 安徽省优秀青年教师基金项目(2009SQRZ119)

关键词基质金属蛋白酶9 基质金属蛋白酶抑制物1 慢性阻塞性肺疾病肺气肿 matrix metalloproteinase-9 matrix metalloproteinase inhibitor-1 chronic obstructive pulmonary disease emphysema

分类号 R563.3 [医药卫生—呼吸系统]

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