中药泡洗防治奥沙利铂所致神经毒性Meta分析

Meta-Analysis of Effects of External Treatments of TCM on Oxaliplatin-induced Neurotoxicity

目的:评价中药泡洗防治奥沙利铂所致神经毒性的疗效。方法 :检索并选取国内公开发表的关于中药泡洗防治奥沙利铂所致神经毒性的随机对照试验文献,对纳入的文献应用Jadad评分法进行质量评价,采用Revman5.0软件进行Mata分析。结果 :共有5项研究符合纳入标准。与对照组比较,中药泡洗防治奥沙利铂所致神经毒性的临床疗效优势比OR合并值为0.26,95%可信区间(CI)为(0.17,0.40)。结论 :根据目前获得的Meta分析结果显示,中药泡洗防治奥沙利铂所致神经毒性的治疗有效,可在临床上广泛应用。

Objectives ： To assess the effects of external treatments of traditional Chinese medicine（ TCM ） on Oxaliplatin-induced neurotoxieity by literature analysis. Method： By using literature search engines, the domestic literature with randomly designed studies with control on the effects of extemal treatments of TCM on Oxaliplatin-induced neurotoxicity was assessed by Meta-analysis with Revman 5.0 after quality control by using Jada Scoring. Results ： All five studies met the standard of selection.Compared with the control, the odds ratio （OR）of the treatments was 0.2 [95% CI （0.17,0.40）]. Conclusions：Based on the Meta-analysis, the external treatments of TCM have clinical effects on controlling Oxaliplatin-induced neurotoxieitv and can be extended to clinics.