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BCRP/ABCG2的结构功能及相关抑制剂研究 被引量：4

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摘要 化学治疗是临床上治疗癌症的一种主要方式。研究发现多重耐药菌（multi—drug resistance，MDR）主要是由一类被称为ABC转运蛋白超家族（ATP binding cassette transporters）的膜蛋白所引起的，它们能够利用ATP水解提供的能量将化学治疗药物排出细胞外，导致肿瘤细胞呈现抗药性。
作者 应帅 郑婷婷 陈培远 郭辉辉 许传莲
机构地区 浙江理工大学生命科学学院
出处 《中国医药生物技术》 2013年第3期201-205,共5页 Chinese Medicinal Biotechnology
基金 浙江省自然科学基金(Y4110320)
关键词 ABCG2 结构功能 BCRP 抑制剂 化学治疗药物 ABC转运蛋白 多重耐药菌 ATP水解
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献54

  • 1Maliepaard M, Scheffer GL, Faneyte IF, et al. Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res, 2001, 61(8):3458-3464.
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二级参考文献11

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  • 2李文通,周庚寅,宋现让,迟伟玲,任瑞美,王兴武.表达BCRP的卵巢癌耐药细胞系3AO/BCRP的建立及其生物学特征[J].基础医学与临床,2006,26(1):61-65. 被引量：3
  • 3张思维,陈万青,孔灵芝,李连弟,鲁凤珠,李光琳,孟佳,赵平.中国部分市县1998～2002年恶性肿瘤的发病与死亡[J].中国肿瘤,2006,15(7):430-448. 被引量：171
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  • 10Ceckova M,Vackova Z,Radilova H,et al.Effect of ABCG2 on cytotoxicity of platinum drugs:interference of EGFP[J].Toxicol In Vitro,2008,22(8):1846-1852.

共引文献6

同被引文献60

  • 1李治,刘春萍,贺艳丽,张景辉,黄韬.乳腺癌干细胞BCRP的表达及意义[J].医学分子生物学杂志,2007,4(6):511-513. 被引量：4
  • 2王金丽,魏敏杰.BCRP生物学特性与乳腺癌耐药性的形成与逆转[J].现代肿瘤医学,2007,15(10):1507-1509. 被引量：4
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二级引证文献9

中国医药生物技术
2013年 第3期

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