血管紧张素受体拮抗剂在心衰中的治疗作用

Therapeutic effect of angiotensin receptor antagonist in treatment of heart failure

目的探讨心血管紧张素受体拮抗剂在心衰中的治疗效果。方法本次研究选择的对象共100例,均为我院2008年1月至2013年1月收治的心衰患者,随机按观察组和对照组各50例划分,对照组采用常规方案治疗,观察组采用血管紧张素受体拮抗剂氯沙坦治疗,回顾两组临床资料。结果观察组50例患者中总有效率为92%,对照组50例患者中总有效率为68%,观察组临床总有效率明显高于对照组,差异有统计学意义(P<0.05)。两组治疗前心搏量(SV)、心脏指数(CI)、心排出量(CO)、左室射血分数(LVEF)无明显差异(P>0.05)。治疗后各指标均有改善,但观察组改善幅度显著优于对照组,差异有统计学意义(P<0.05)。结论心衰患者采用血管紧张素受体拮抗剂治疗,可显著提高临床效果,改善心功能,降低不良反应率,具有非常积极的临床意义。

Objective To investigate the therapeutic effect of angiotensin receptor antagonist in the treatment of heart failure. Methods A total of 100 patients with heart failure, who were admitted to our hospital from January 2008 to January 2013, were randomly divided into observation group （n = 50） and control group （n = 50）. The control group received conventional treatment, while the observation group received angiotensin receptor antagonist losartan. The clinical data of the two groups were retrospectively analyzed. Results The observation group had a significantly higher overall response rate than the control group （92% vs 68%, P〈0.05）. There were no significant differences in stroke volume, cardiac index, cardiac output, and left ventricular ejection fraction between the two groups before treatment （P〉0.05）. After treatment, both groups had a significant improvement in the above indices, but the observation group showed significantly more improvement （P〈0.05）. Conclusion ngiotensin receptor antagonist can improve cardiac function and reduce adverse effects in patients with heart failure and produce a significantly better treatment outcome. It shows promise for clinical application.