48例短暂性脑缺血发作临床治疗分析

Clinical treatment of transient ischemic attack: an analysis of 48 cases

目的研究分析短暂性脑缺血发作的临床治疗方法和治疗效果。方法回顾性分析2011年1月-2012年6月期间,我科收治的48例短暂性脑缺血发作患者的临床资料,按照患者治疗期间所采用的治疗方式不同,将其随机分为两组,对照组24例,采用阿司匹林治疗,观察组24例,采用氯吡格雷治疗,比较两组患者的治疗效果和不良反应情况。结果治疗后对照组患者的有效率为95.83%,观察组为91.67%,两组间比较无明显差异,差异无统计学意义(P>0.05),且治疗过程中两组患者均未见肾功能、血糖、血压等方面的不良反应。结论阿司匹林和氯吡格雷都是治疗短暂性脑缺血发作的良好药物,两种药物疗效相当,但阿司匹林的价格相对低廉,值得临床推广。

Objective To analyze the clinical treatment of transient ischemic attack （TIA） and the treatment outcome. Methods A retrospective analysis was performed on the clinical data of 48 patients with TIA who were admitted to our department from January 2011 to June 2012. The patients were randomly divided into control group （n=24） and observation group （n=24）. The control group received aspirin, while the observation group received clopidogrel. The two groups were compared in terms of treatment outcome and adverse events. Results The control group had a response rate of 95.83%, versus 91.67% in the observation group （P〉0.05）. Neither group had adverse events concerning renal function, blood glucose, and blood pressure during treatment. Conclusion Aspirin and clopidogrel are good medicines in treating TIA, and they have comparable therapeutic effects. However, aspirin is relatively inexpensive and holds promise for clinical application.