杨桃叶总黄酮的降血糖作用

Hypoglycemic Effect of Total Flavones from Carambola Leaf

目的:探讨杨桃叶总黄酮对糖尿病大鼠模型的血糖影响。方法:小鼠腹腔注射四氧嘧啶80 mg.kg-1,大鼠腹腔注射链脲佐菌素40 mg.kg-1复制高血糖模型,随机分为模型对照(蒸馏水)组、格列本脲对照(0.3 g.kg-1)组、杨桃叶总黄酮高、中、低剂量(0.8,0.4,0.2 g.kg-1)组,另设空白组(蒸馏水)每组10只。连续灌胃7 d,末次药后1.5 h采血,测定动物的空腹血糖和葡萄糖耐量。结果:杨桃叶总黄酮高、中剂量显著降低高血糖模型大鼠和小鼠的空腹血糖,提高模型大鼠和小鼠的葡萄糖耐量。结论:杨桃叶总黄酮具有改善链脲佐菌素或四氧嘧啶诱发的高血糖和糖耐量作用。

Objective： To investigate the influence of the total flavones from Carambola leaf （TFCL） in decreasing blood sugar level in animals with diabetes mellitus （DM）. Method： DM mouce model was induced by abdominal injection of alloxan 80 mg·kg^-1 and DM rat model was induced by abdominal injection of streptozocin 40 mg·kg^-1 respectively. Successful model animals confirmed by detecting fasting blood-glucose were randomly divided into 5 groups： normal control group （distilled water）, model group （distilled water）, glibenclamide group （0.3 g·kg^-1）, high,medium and low dosage groups of TFCL （0.8, 0.4, 0.2 g·kg^-1）. The drugs were given daily for 7 consecutive days. After 1.5 h of last administration of drugs, the influence of TFCL on blood sugar level in DM mice and rats was observed. Result： TFCL （high and medium dosages） could decrease the blood sugar level and enhance glucose tolerance significantly in DM mice and rats. Conclusion： TFCL has hypoglycemic and enhancing glucose tolerance effects in DM mice and rats.