中西医结合治疗非小细胞肺癌

Clinical Research of Combining Traditional Chinese Medicine with Western Medicine to Treat Non-small Cell Lung Cancer

目的:探讨中西医结合治疗非小细胞肺癌患者的治疗效果。方法:选择2009年6月-2012年6月106例非小细胞肺癌(Ⅲb,Ⅳ期)住院患者,其中对照组54例,采用多西紫杉醇75 mg.m-2静脉点滴1 d,顺铂25 mg.m-2,1～3 d,多西紫杉醇使用前6,12 h分别口服地塞米松8 mg,前0.5 h肌注苯海拉明40 mg,静注西咪替丁300 mg。化疗时常规给予止吐药物。研究组52例,在对照组治疗基础上加用艾迪50 mL加入10%葡萄糖溶液静脉点滴,每天1次治疗,两组持续治疗12周。观察并比较两组的疗效,平均疾病进展时间以及生活质量提高率和降低率。结果:对照组的总有效率为48.1%,研究组的治疗总有效率64.8%,两组相比差异具有统计学意义(P<0.05)。对照组和研究组的平均疾病进展时间分别为128.35,174.56 d,两组相比差异具有统计学意义(P<0.05);两组生活质量提高率和降低率比较,对照组卡氏功能状态(KPS)评分提高10例(19.2%),稳定13例(25%),降低29例(55.8%),研究组KPS评分提高为18例(33.3%),稳定13例(24.1%),降低23例(42.6%),两组提高率和降低率比较,差异具有统计学意义(P<0.05)。结论:中西医结合治疗非小细胞肺癌的治疗效果显著,生存时间长,疾病进展时间较长,对改善患者的生活质量发挥作用,值得推广。

Objective： Discussion on combination of traditional Chinese and Western medicine in treatment of patients with non-small cell lung cancer（NSCLC）treatment. Method： Choose sixty-six patients with non-small cell lung cancer （Ⅲ,Ⅳperiod） who were received and cured in our hospital from June 2009 to June 2012,these patients were intravenous dropped docetaxel 75 mg·m^-2 and cisplatin 25 mg·m^-2,the former was d1 and the latter was d1-3, before using hexadecadrol 6 h and 12 h,the patients could respectively take orally dexamethasone 8 mg, former 0.5 h and were intramuscular injection diphenhydramine 40 mg, static injection cimetidine 300 mg. Giving stop vomiting drugs when they were proceeding to conventional chemotherapy, 54 cases regarded as control group and were treated in this way.52 cases in the treatment were treated with 50 milliliter Eddie based on control group and joined 10% glucose solution to intravenous drop, one treatment every day. Two groups were continuously treated for 12 weeks. Observe and compare the efficacy of two groups, average rates of disease progression time and improved quality of life and reduce rates. Result： Total effective rate of 48.1% per cent of the control group, the study group total effective rate in the treatment of 64.8%, compared to the two groups, the difference statistically significant （P〈0.05）; control group and the study group＇s average time of disease progression respectively 128.35, 174.56 d,compared to the two groups, the difference statistically significant （P〈0.05）; compared of two groups improved quality of life and reduce rates efficacy, control group karnofsky（KPS） score increase 10 （19.2%）,stable 13 cases （25%）, reduced in 29 cases （55.8%）, research group KPS scores improve to 18 cases （33.3%）, stable in 13 cases （24.1%）, reduced 23 cases （42.6%）, compared of two groups improved quality of life and reduce rates efficacy, the difference statistically significant （P〈0.05）. Conclusion： Effect treated with combination of traditional Chinese and Western medicine in the treatment of non-small cell lung cancer significantly, living longer, disease progression time for longer, play a role in improving the quality of life for patients with that merits promotion.