眼表重建术后局部应用FK-506的初步临床观察

Priliminary clinical observation of topical use of FK 506 after ocular surface reconstruction

目的 寻找眼表重建术后主要并发症的有效治疗措施。方法 对 32例 32只严重化学伤患眼施眼表重建术 (板层角膜移植、角膜缘移植及羊膜移植术 ) ,随机将研究对象分为治疗组及对照组 (各 16只眼 ) ;治疗组于术后 1wk局部应用 0 .5 g· L- 1的 FK- 5 0 6滴眼液 ,对照组应用 10 g· L- 1 Cs A滴眼液 ,观察 2组角膜新生血管指数、移植组织的排斥反应指数。结果 在随访期内 ,治疗组的组织排斥反应时间、发生率、角膜假性胬肉及睑球粘连 4个指标均明显优于对照组。结论 局部应用 FK- 5 0 6可有效提高眼表重建术的成功率。

Objective To find out effective treatments for complications after ocular surface reconstruction. Methods Lamellar keratoplasty, limbal stem cell and human amniotic membrane transplantation were performed on 32 patients(32 eyes) suffering from severe chemical burns, who were divided into the therapeutic group (16 eyes)and control group(16 eyes)randomly. While they were given the same routine treatment with cortisone, the therapeutic group and the control group received additional ophthalmic solution with FK 506(0.5g·L -1 ) and 10g·L -1 CsA in the same time respectively. The rejection indexs of transplanted tissue were observed. Results In follow up period the therapeutic group was significantly better than control group in graft rejection and prognosis. Conclusion The local applying of FK 506 can improve the rate of success in ocular surface reconstruction greatly.