2,3-二甲氧基丙酸甲酯的合成

Synthesis of Methyl 2,3-Dimethoxypropanoate

以丙烯酸甲酯、溴素为原料合成2,3-二溴丙酸甲酯,然后与甲醇钠反应合成2,3-二甲氧基丙酸甲酯。通过条件实验获得了较佳反应条件:n(甲醇钠)∶n(2,3-二溴丙酸甲酯)=1.8∶1.0,反应温度为20℃,反应时间为10 h。在该条件下,2,3-二甲氧基丙酸甲酯含量达68.7%(GC),精馏纯化收率达57.8%。

Methyl 2,3-dibromopropanoate was synthesized from methyl acrylate by reaction with bromine,and then converted into methyl 2,3-dimethoxypropanoate by reaction with sodium methoxide.The reaction conditions were optimized under which the target product was obtained in 57.8% yield with a purity of 68.7%（GC）.