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免疫缺陷患者嗜麦芽寡养单胞菌败血症9例

Clinical analysis of 9 patients with Stenotrophomonas maltophilia septicemia and hematonosis
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摘要 目的:探讨血液科免疫力低下患者嗜麦芽寡养单胞菌败血症的临床特点、治疗及预后。方法 :回顾分析本院2001年以来血液病合并嗜麦芽寡养单胞菌败血症9例患者的临床资料。结果:所有患者均有使用广谱β内酰胺类和喹诺酮类药物史,89%的患者有静脉置管史,该菌对多数抗菌药物耐药,但对复方新诺明、左氧氟沙星及米诺环素较为敏感,经验性治疗有效率低(33.3%),针对性治疗后可提高有效率(77.7%),但是体外药敏结果与临床治疗结果并非完全一致。结论:缩短中性粒细胞缺乏及静脉置管的时间,有可能减少嗜麦芽寡养单胞菌败血症的发生,针对性治疗可适当提高其治疗有效率,经验性联合用药也可以发挥抗药疗效。 Objective To investigate the clinical characteristics,therapy and outcome of Stenotrophomonas maltophilia(S.maltophilia) septicemia in 9 patients with hematonosis.Methods Clinical data of 9 patients with hematonosis combined with S.maltophilia septicemia were retrospectively analyzed.Results All patients had a history of long-term use of extended-spectrum β lactamases and quinolones,89% of patients had indwelling venous catheterization.S.maltophilia was resistant to many commonly used antimicrobial agents,but was marginally sensitive to cotrimoxazole,levofloxacin and minocycline.The efficiency of empirical treatment was lower and that of pertinency treatment(33.3% vs.77.7%).Clinical treating results were inconsistent with the sensitivity testing results in vitro.Conclusion It is likely to prevent S.maltophilia septicemia by shortening the duration of the lacks of neutrophils and indwelling venous catheterization,pertinency treatment can partially increase the efficiency,empirical treatment with combination drugs may also work.
机构地区 南方医院血液科
出处 《实用医学杂志》 CAS 北大核心 2013年第10期1629-1631,共3页 The Journal of Practical Medicine
关键词 败血症 嗜麦芽寡养单胞菌 血液病 Septicemia Stenotrophomouas mahophilia Hematology
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