慢性心力衰竭患者血浆脑钠肽水平检测的临床意义

Clinical Significance of Plasma BNP Detection in Chronic Heart Failure Patients

目的分析176例慢性心力衰竭(CHF)患者的血浆脑钠肽(BNP)水平,探讨其对CHF早期诊断和治疗的临床意义。方法化学发光免疫分析测定CHF患者组(n=176)及正常对照组(n=102)血浆BNP水平并进行对比。对CHF患者进行抗CHF药物综合治疗,对比分析治疗前后血浆BNP水平。结果 CHF组血浆BNP水平明显高于正常对照组(P<0.05),随着CHF程度加重,血浆BNP浓度升高(P<0.05)。CHF组经药物综合治疗后,血浆BNP水平明显降低(P<0.05)。结论血浆BNP水平检测对CHF的诊断、评估疾病的严重程度、危险分层和预后评价有重要价值。

Objective To analyze the plasma BNP levels and its clinical significance of early diagnosis and treatment in patients with chronic heart failure （CHF）. Methods The levels of plasma BNP were measured by chemiluminescence analysis in 176 CHF patients and 102 normal controls, and comparative analysis was performed. Moreover, a comprehensive treatment was carried out for the CHF patients,and the levels of plasma BNP were compared before and after treatment. Results The BNP levels of plasma CHF were significantly higher than the control group （P 〈 0.05 ）, and it was increased with the severity of CHF exacerbation （P 〈 0.05 ）. After comprehensive treatment, plasma BNP levels were significantly reduced （P 〈 0.05）. Conclusion The detection of plasma BNP level has important value in diagnosis of CHF, estimate of the severity of disease, risk stratification, and prognosis evaluation.