加味葛根芩连汤结合肛塞清肠栓治疗溃疡性结肠炎的效果观察

Clinical effects of Modified Gegenqinlian Decoction combined with per rectum Qingchangshuan in the treatment of ulcerative colitis

[目的]观察加味葛根芩连汤联合肛塞清肠栓治疗溃疡性结肠炎的临床疗效。[方法]120例轻-中度溃疡性结肠炎患者被随机分为:口服加味葛根芩连汤联合肛塞清肠栓组(L组)、口服加味葛根芩连汤组(G组)、肛塞清肠栓组(Q组)、口服柳氮磺胺吡啶组(S组),每组30例。观察比较各组患者治疗前后症状总积分、黏液脓血便、里急后重等单项症状积分及肠镜下表现积分的变化。[结果]L组能有效改善患者总体症状和肠镜检查所见的病理表现,且优于其他3组疗法,总有效率为96.67%;在改善"里急后重"和"黏液脓血便"症状方面,也较其他3组疗法起效更快。[结论]加味葛根芩连汤联合肛塞清肠栓能有效改善溃疡性结肠炎患者的总体症状和肠镜下病理表现。

[Objective]To observe the clinical effects of Modified Gegenqinlian Decoction （MGD） com- bined with per rectum Qingchangshuan in the treatment of ulcerative colitis（UC）. [Methods]One hundredand twenty cases of mild to moderate UC patients were randomly divided into 4 different therapeutic groups （each n=40）. Group L was treated by MGD and per rectum Qingchangshuan, Group G was trea- ted by MGD, Group Q was treated by per rectum Qingchangshuan and Group S was treated by sul- fasalazine. The clinical effects were evaluated by colonoscopy results and individual symptoms （mucous, pu- rulent discharge and blood in stool, tenesmus i. e. ）. [Results]The colonoscopy findings and the total scores of symptom changes were effectively improved in Group L, which was superior to the other three groups. The total effective rate was 96.67 % in Group L, and the relief of symptoms such as tenesmus, mucus, pu- rulent discharge and bloody stools was particularly faster when compared with other three treatments groups. [-Conclusio]MGD combined with per rectum Qingchangshuan could improve the symptoms of UC as well as its pathological findings under colonoscopy.