疏肝和胃冲剂治疗非溃疡性消化不良的临床疗效

Clinical study of Suganhewei instant granules on non-ulcer dyspepsia

[目的]探讨疏肝和胃冲剂治疗非溃疡性消化不良(NUD)的临床疗效。[方法]通过检测NUD患者经疏肝和胃冲剂、吗丁啉治疗前后血清胃泌素、胃动素及三维超声胃半排空时间,结合中医症状积分,综合评价2组药物的临床疗效。[结果]2组患者经药物治疗后症状总积分明显减少,血清胃泌素下降,胃动素升高,胃半排空时间缩短;与治疗前比较,差异有显著统计学意义(P<0.01)。疏肝和胃冲剂治疗后症状总积分及各项临床检测指标较吗丁啉治疗后改善更明显,差异有统计学意义(P<0.01)。[结论]疏肝和胃冲剂治疗NUD疗效可靠、无明显不良反应,具广泛的临床应用前景。

[Objective]To evaluate the effect of traditional Chinese medicine Suganhewei instant granules （SIG） in improving gastric emptying of patients with non-ulcer dyspepsia（NUD）. [Methods]One hundred and thirty patients of NUD were enrolled and treated with SIG （n= 100） and domperidone （n=30）respec- tively for 4 weeks. The changes of TCM symptom scores,serum gastrin,plasma motilin,and half-time ofliquid gastric emptying before and after treatment were observed. [Results~ Compared with those before treatment,the TCM symptom scores were improved,level of serum gastrin was decreased and motilin was increased, half-time gastric emptying was shortened significantly after treatment （P〈0.01）. And the TCM symptom scores were improved much more significant in SIG group than in domperidone group （P〈 0.01）. [Conclusion]The present study suggested that SIO could improve the gastric emptying in patients of NUD without side effects.