2型糖尿病及其血管并发症患者血清ACE活性的变化

The Changes of Serum Angiotensin Converting Enzyme Activity in Type 2 Diabetes and Its Vascular Complications

为了解2型糖尿病及其血管并发症患者血清ACE(SACE)活性的变化， 采用比色法对1 27例2型糖尿病患者和90例正常人进行SACE活性的检测。结果显示：糖尿病患者SACE活性(45 9. 51±175.85U)明显高于正常人(321.14±121.27U)；糖尿病肾病组SACE活性(548.27±166.60 U)明显高于非肾病组(383.20±139-00U)，但微量蛋白尿组(528.10±190.70U)与大量蛋白 尿 组(545.83±138.60U)SACE活性比较无统计学意义(P＞005)；糖尿病视网膜病变 组SACE活性(465.64±178.93 U)与无视网膜病变组(449.07±170.04U)比较也无统计学意义；糖尿病患者SACE活性与病程 、 血压、血脂和血糖无关。提示ACE可能仅参与了糖尿病和糖尿病肾病的发病，而与糖尿病肾 病进行性发展、糖尿病视网膜病变和高血压发病无关。

This investigation was made with reference to the changes of s erum angiotensin converting enzyme(SACE) activity in type 2 diabetes and its vascular complications. SACE activity was studied in 127 type 2 diabetic patients and 90 healthy persons by using a spectrophotometric assay. The results showed SACE ac tivity was obviously higher in diabetic patients (459.51*175.85U) than in healt hy persons (321.14*121.27U); SACE activity was significantly higher in type 2 d iabetic patients with diabetic nephropathy (548.27*166.60U) than in patients wi thout diabetic nephropathy (383.2*139.00U), but there was no difference between patients with microalbuminuria and macroalbuminuria; no statistical difference was detected in SACE activity between diabetic patients with diabetic retinopath y (465.64*178.93U) and without retinopathy (449.07*170.04U); SACE activity was not associated with the course of diabetes, blood pressure, blood lipid and blo od glucose. These data suggest that raised SACE activity might only play a role in the initiation of type 2 diabetes and diabetic nephropathy, but not relate to the progress of diabetic nephropathy, the onset of diabetic retinopathy and hypertension.