摘要
棕色脂肪组织(BAT)在维持体温恒定和调节能量代谢方面发挥着重要的生理作用。近年来研究发现,寒冷刺激可促进成人体内出现棕色样脂肪细胞,这种脂肪细胞的基因表达谱介于白色脂肪细胞和经典的棕色脂肪细胞之间,于是提出了"白色脂肪细胞棕色化"的概念,且认为过氧化物酶体增殖物激活受体γ、肌肉抑制素、成纤维细胞生长因子21、irisin等因子参与了这一过程。白色脂肪细胞棕色化后,能显著促进机体能量的消耗,改善机体糖脂代谢,因此,可能成为针对肥胖症及其相关代谢异常疾病治疗的新靶点。
The brown adipose tissue（BAT） plays an important role in maintaining body temperature and energy balance.Recent studies demonstrated that brown-like adipocytes emerged in adults who have been exposed to the cold.The phenotype of this kind of cells is between white adipocytes and classic brown adipocytes.Therefore,the concept of browning of white adipocytes is put forward.A growing body of evidence indicates that several factors are proposed to be associated with the browning of the white adipocytes,including PPARγ,myostatin,FGF21 and irisin.The browning of WAT can significantly promote the energy consumption,improve glucose and lipid metabolism.Therefore it might be the therapeutic target for obesity and its related metabolic disorders.
出处
《医学综述》
2013年第10期1729-1732,共4页
Medical Recapitulate
基金
国家自然科学基金(30540036
30771026)
北京市自然科学基金(7082079)
