前列腺素在子宫内膜异位症中的研究进展

Research Progress of Prostaglandin in Endometriosis

子宫内膜异位症(EMs)是育龄期妇女的常见疾病,发病率为5%～10%,是引起女性不孕的主要原因。患者多出现慢性盆腔痛、痛经、性交困难等症状,严重影响生活质量。EMs的病因复杂,其确切发病机制目前仍不明确。前列腺素E2(PGE2)是一种不稳定型的类花生四烯酸化合物,越来越多的证据表明,PGE2在EMs的病理生理过程中发挥关键作用,如细胞增殖、抗凋亡、免疫抑制和血管生成等。

Endometriosis is the primary cause of infertility in women,with a prevalence ranging from 5% to 10%.Women with endometriosis suffer from symptoms such as chronic pelvic pain,dysmenorrhea and dyspareunia,which significantly reduce the quality of life.The etiology of Ems is complex,and the exact pathogenesis is still unclear.Prostaglandin E2（PGE2） is an unstable eicosanoid.A growing body of evidence demonstrates that PGE2 regulates many pathophysiological processes including cell proliferation,antiapoptosis,immune suppression and angiogenesis.