摘要
目的 :研究大鼠头端延髓腹外侧区 (RVL M)谷氨酸 NMDA受体在介导动脉压力感受器反射 (ABR)中的作用。 方法 :在氨基甲酸乙酯麻醉的大鼠 RVL M双侧各微注射 0 .1μl的 5 0 mm ol/L氯胺酮 ,观察动脉血压、心率以及 ABR的变化。结果 :双侧 RVL M内微注射氯胺酮后动脉血压和心率明显下降 (P<0 .0 5 ) ,同时能部分或完全阻断 ABR(P<0 .0 5 )。结论 :谷氨酸 NMDA受体在维持交感心血管活动的紧张性兴奋和介导 ABR中具有十分重要的作用。
Objective: To study the roles of N methyl D aspartate acid (NMDA) receptors of glutamate in mediating the arterial baroreceptor reflex (ABR)in rostral ventrolateral medulla (RVLM) in rats. Methods: The blood pressure, heart rates and ABR were observed after the bilateral microinjection of 0.1 μl 50 mmol/L ketamine into RVLM of ureth anesthetized rats. Results: Bilateral microinjection of ketamine into RVLM induced decrease of the blood pressure and heart rate ( P <0.05), and partial or complete blockade of ABR ( P <0.05). Conclusion: NMDA receptor of glutamate plays an important role in maintaining the sympathetic cardiovascular excitatory tone and mediating ABR. [
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2000年第8期739-741,共3页
Academic Journal of Second Military Medical University
关键词
头端延髓腹外侧区
动脉压力感受器反射
NMDA受体
receptors
N methyl
D
aspartate acid
rostral ventrolateral medulla
arterial baroreceptor refl
