MMP-2及CD_(105)在唾液腺肿瘤浸润、转移机制中的作用研究进展

Research Progress in the Roles of MMP-2 and CD_(105) Related to Infiltration and Metastasis Mechanism of Salivary Gland Tumors

唾液腺肿瘤是人体特有的一大类肿瘤,绝大多数系上皮性肿瘤,间叶组织来源的肿瘤较少见。唾液腺肿瘤病理类型复杂而且具有一定的浸润、转移特性。多年研究发现,具有恶性倾向的唾液腺肿瘤中,基质金属蛋白酶2(MMP-2)及Endoglin(CD105)表达水平明显高于良性肿瘤,因此研究MMP-2及CD105在唾液腺肿瘤中的表达情况,对该类肿瘤浸润、转移机制的研究具有重要意义。

Salivary gland tumor is a large class of human-specific tumors.The vast majority of the tumors are epithelial tumors and tumors of mesenchymal tissue sources are rarely seen.Salivary gland tumor pathological type is complex and has a certain degree of infiltration,transfering characteristics.Through years of research it＇s found that matrix metalloproteinase-2（MMP-2） and Endoglin（CD105） expression are significantly higher in tumors with malignant tendency than benign salivary gland tumor,therefore studying the expression of MMP-2 and CD105 in salivary gland tumors is of great significance for studing the mechanisms of the tumor invasion and metastasis.Here is to make a review on the research progress of MMP-2,CD105 in salivary gland tumors invasion and metastasis.