替加色罗联用聚乙二醇治疗便秘型肠易激综合征的临床观察

Clinical Observation on Tegaserod Combined with Polyethylene Glycol Treatment of Constipationpredominant Irritable Bowel Syndrome

目的观察替加色罗联用聚乙二醇治疗便秘型肠易激综合征(C-IBS)的临床疗效。方法选择2009年3月至2012年3月在四平市中心人民医院消化内科就诊的138例C-IBS患者为研究对象,上述患者随机分为三组:联合治疗组(50例)采用替加色罗联用聚乙二醇,替加色罗组(43例)仅应用替加色罗治疗,莫沙必利组(45例)仅应用莫沙必利治疗。记录治疗期间三组患者每日的排便次数、大便Bristol分级及腹部胀痛等改善情况。结果治疗后三组结肠传输时间均少于治疗前(P<0.05),联合用药组和替加色罗组治疗后的结肠传输时间显著少于莫沙必利组(P<0.05);联合治疗组和替加色罗组腹痛、腹胀改善情况显著优于莫沙必利组(P<0.05);治疗后各组大便Bristol的分级构成与治疗前相比,差异有统计学意义(P<0.05)。结论替加色罗联合聚乙二醇治疗C-IBS,近期取得较好的疗效,但远期疗效仍需进一步观察。

Objective To observe the clinical efficacy of Tegaserod combined with polyethylene glycol as the treatment of constipation-predominant irritable bowel syndrome（C-IBS）.Methods One hundred and thirty-eight patients with C-IBS from Gastroenterology Department in Siping Central People＇s Hospital from March 2009 to March 2012 were selected for the study,and were randomly divided into 3 groups： the combined treatment group（50 patients） received tegaserod combined with polyethylene glycol,tegaserod group（43 cases） received only tegaserod,the mosapride group（45 patients） received mosapride.And daily defecation,stool Bristol grading,improvement of abdominal pain of the patients of the three groups were recorded.Results After treatment,colonic transit time of the three groups was significantly shorter than before treatment（P 0.05）,the colonic transit time of combined treatment group and tegaserod group after treatment was significantly shorter than mosapride group（P 0.05）;compared with mosapride group,abdominal pain and distension of combined treatment group and tegaserod group improved significantly（P 0.05）;the difference of hierarchically structured stool Bristol of different groups before treatment and after treatmentwas statistically significant（P 0.05）.Conclusion Tegaserod combined with polyethylene glycol as treatment of C-IBS has good short-term results,while the long-term effect needs further observation.