全氟戊烷微滴乳剂增强HIFU疗效的研究

Perfluoropentane Droplets Enhanced HIFU Therapeutic Effect

用小型HIFU系统,详细研究了在体内激发全氟戊烷微滴乳剂变成微泡及其在胶体内的热吸收规律。试验证明,该小型HIFU系统能在体激发全氟戊烷微滴乳剂,转化为体积增大数十倍的微泡;适宜浓度的全氟戊烷微滴乳剂能有效加强HIFU辐照形成的损伤。

A small HIFU system was used to investigate the phase-shift droplet vaporization in vivo and its effect on thermal absorption in tissue-mimicking phantoms. The experiments demonstrated that droplets could be vaporized to bubbles in vivo by the small HIFU system and the volume of bubbles could increase by tens of times. With appropriate droplets concentration, lesion volume produced by HIFU could be increased significantly under the same HIFU parameter.