摘要
目的:探讨复方益肝灵预防抗结核药物致肝损伤的临床疗效。方法:采用前瞻性研究,对384例门诊肺结核患者随机分为复方益肝灵治疗组192例和对照组192例,前者予复方益肝灵(主要成分为水飞蓟素和五味子提取物五仁醇浸膏)和抗结核药物联合治疗,后者进行常规抗结核治疗并加服葡醛内酯片,6~8个月为1疗程,疗程结束后比较2组的临床症状、体征和肝功能变化情况。结果:加用复方益肝灵后,治疗组肺结核患者发生药物性肝损伤41例,病情轻微,而对照组发生药物性肝损伤138例,发生率分别为21.4%和71.9%,2组比较具有统计学意义(P〈0.05)。2组抗结核治疗过程中治疗组有7例(3.6%)、对照组有21例(10.9%)中断抗结核治疗,2组比较有统计学意义(P〈0.05)。结论:复方益肝灵可有效预防抗结核药物所致的肝损伤,不良反应少且轻微。
Objective: To assess the clinical efficacy of compound liver-benepitino remedy in preventing liver injurycaused by antituberculosis drugs. Methods:We divided 384 tuberculosis patients into treatment group and control group ran- domly. The former were treated with compound liver-benepitino remedy and antituberculosis drugs, and the later were treated with antitubereulosis drugs and glucurolactone tablets. The course of the treatment was from 6 months to 8 months, and after completing the treatment, compare the clinical symptoms, physical signs and the function of liver between two groups. Re- suits:In treatment group (192 cases), 41 patients had the slight liver injure, but in control group, 138 patients had the liver injure. The incidences were 21.4 % in treatment group and 71.9 % in control group respectively, and the difference was sta- tistically significant ( P 〈 0.05). In process of treatment, 7 (3.6 % ) patients' treatments were discontinued, and 21 ( 10.9 % ) patients' treatments were discontinued, the difference between two groups was statistically significant (P 〈 0.05). Conclu- sions:Compound liver-benepitino remedy can prevent the liver injure caused by antituberculosis drugs, there are less side ef- facts, anrl the side effects also were slight, so it have some clinical value.
出处
《长春中医药大学学报》
2013年第1期43-45,共3页
Journal of Changchun University of Chinese Medicine
关键词
肝损伤
抗结核药
预防
控制
复方益肝灵
liver injure
antituberculosis drugs
prevent and control
compound liver-benepitino