四种益生元聚糖对高脂血症仓鼠血脂的影响

Hypolipidemic Effects of Four Species of Prebiotics in Hyperlipidemic Hamsters

探讨聚葡萄糖,聚木糖,菊粉,阿拉伯半乳聚糖四种聚糖类益生元对高血脂仓鼠的血脂调节作用。采用高脂饲料喂饲健康成年雄性仓鼠,以诱发高脂血症,同时分别喂饲添加0.5%的聚葡萄糖,聚木糖,菊粉,阿拉伯半乳聚糖(AG)的高脂饲料,观察四种益生元聚糖对仓鼠血清胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白胆固醇(HDL-C)含量的影响。结果表明:1)四种益生元聚糖均能显著性降低进食高脂饲料仓鼠的空腹血清总胆固醇(TC)和非高密度脂蛋白胆固醇(Non-HDL-C)含量;2)除阿拉伯半乳聚糖外,其它三种益生元聚糖均能显著性地降低喂饲6周仓鼠肝脏组织TC含量,四种益生元聚糖均能显著性降低肝脏TG水平。因此,四种益生元聚糖具有较显著的调节血脂的作用。

To explore the effects of several prebiotics that polydextrose, polyxylose, inulin, arabinogalactan （AG） on the level of blood lipid in hamsters. The animal model of hyperlipidemia in healthy male hamsters was established by feeding diets riehed in high cholesterol, in the meantime the four prebiotics were given at a level of 5 % in the diets. Observe the effects of four prebiotics on the total cholesterol （TC）, triglycerides （TG） and high density lipoprotein cholesterol （HDL-C） in serm and liver of hamsters. Results showed： 1 ） the prebiotics could reduce the levels of serum TC and Non-HDL-C of hamsters fed on a lipid rich diet obviously, while the level of TG and HDL-C in serum did not changed in all groups during the experiment. 2） the prebiotics could reduce the total cholesterol levels in liver tissue of hamsters obviously except for arabinogalactan. And all prebiotics could decrease triglyceride in liver tissue obviously. Therefore the four prebiotics could regulate the lipid of blood observably.