IGF-Ⅱ、PCNA在子宫肌瘤患者诊断中的意义

The expression and clinical significance of IGF-Ⅱand PCNA in hysteromyoma

目的探讨胰岛素样生长因子Ⅱ(IGF-Ⅱ)联合增殖细胞核抗原(PCNA)在子宫肌瘤诊断中的临床意义。方法本院2008年1月～2012年3月40例病理证实子宫肌瘤患者设为观察组,取其子宫肌瘤组织进行观察,同期40例病理证实卵巢良性肿瘤患者设为对照组,取其子宫平滑肌组织进行观察,采取免疫组化的方法对两组患者的组织中的IGF-Ⅱ、PCNA表达水平进行测定。结果观察组IGF-Ⅱ、PCNA表达水平与对照组相比,差异有统计学意义(P<0.05),观察组表达水平高于对照组。结论 IGF-Ⅱ、PCNA在肿瘤组织中高表达,提示其与子宫肌瘤的发生发展相关。

Objective To investigate the expression and clinical significance of insulin-like growth factor- Ⅱ （IGF- Ⅱ ） and proliferating cell nuclear antigen （PCNA）in diagnosis of hysteromyoma. Methods The 40 cases of patients with hysteromyoma confirmed by pathology in our hospital from January 2008 to March 2012 were selected as observation group, the uterine fibroids tissue were observed, forty eases of patients with ovarian benign tumor confirmed by pathol- ogy during the same period were selected as control group, the uterine smooth muscle tissue were observed. Immuno- histoehemical method was employed to detect the expression of IGF-Ⅱ and PCNA in the hysteromyoma and the nor- real control group. Results The expression of IGF-Ⅱ and PCNA in observation group were higher than control group, there was significant difference between the uterine leiomyoma and the normal myometrium（P 〈 0.05）. Conclusion The high expression of IGF- Ⅱ and PCNA in hysteromyoma indicates that IGF-Ⅱ and PCNA is related with the develop- ment of hysteromyoma.