妊娠期高血压疾病血清中HGF、AngⅡ水平的变化及意义

Changes and significance of serum HGF,AngⅡ in hypertensive disorders in pregnancy

目的检测妊娠期高血压疾病孕妇血清肝细胞生长因子(hepatocyte growth factor,HGF)、血管紧张素Ⅱ(AngⅡ)的水平,探讨二者变化的意义。方法采用双抗夹心酶联免疫吸附法(ELISA)测定72例妊娠期高血压疾病孕妇和23例正常妊娠孕妇血清HGF、AngⅡ水平。结果妊娠期高血压组[(145.7±17.2)pg/mL]、子痫前期组[(141.6±16.0)、(135.0±14.3)pg/mL]血清HGF水平较对照组[(211.6±20.8)pg/mL]降低(P<0.01);妊娠期高血压组[(97.5±11.0)ng/mL]、子痫前期组[(119.7±13.9)、(135.4±19.2)ng/mL]血清AngⅡ水平较对照组[(45.6±9.4)ng/mL]明显升高(P<0.01),妊娠期高血压组、轻度子痫前期、重度子痫前期血清AngⅡ水平逐次升高,组间比较差异有统计学意义(P<0.05)。结论妊娠期高血压疾病孕妇血清HGF水平降低,血清AngⅡ水平逐渐升高,提示二者可能参与了妊娠高血压疾病的发生和发展。

Objective To investigate the changes and values of serum HGF and Ang Ⅱ in hypertensive disorders in pregnancy. Methods Serum level of HGF and Ang Ⅱ were measured with enzyme linked immunosorbent assay （ELISA） in 72 cases of hypertensive disorders in pregnancy and 23 cases normal pregnant. Results Serum level of HGF were （145.7±17.2） pg/mL in gestational hypertension groups and [（141.6±16.0）, （135.0±14.3） pg/mL] in pre-eclampsia groups, both of them were significant lower than （211.6±20.8） pg/mL of normal pregnant groups; Serum level of Ang Ⅱ in ges- tational hypertension were （97.5±11.0） ng/mL and [（119.7±13.9）, （135.4±19.2） ng/mL] in preeclampsia, both of them were significant higher than （45.6±9.4） ng/mL of normal pregnant groups, and serum level of Ang Ⅱ were gradually increased in gestational hypertension, mild pre-eclampsia and severe pre-eclampsia groups, there were significant differences a- mong them （P 〈 0.05）. Conclusion The changes of serum level of HGF and Ang H were concerned with the occur- rence and development of hypertensive disorders in pregnancy